Obese patients with kidney tumors are 48 percent more likely to develop clear-cell renal cell cancer (RCC) than patients with a body mass index (BMI) of less than 30. In addition, the odds of developing clear-cell RCC increase by 4 percent with every extra BMI point.
These findings come from a study conducted by a research team at Memorial Sloan-Kettering Cancer Center in New York. The study included data collected from 1,640 patients with kidney tumors. Approximately 88 percent of the participants had malignant tumors, and 61 percent of these were clear-cell RCC. Researchers found a substantial association between obesity and the risk for developing clear-cell RCC.
Lead author William T. Lowrance commented on the findings: "A number of studies have suggested that obesity could be a risk factor for RCC, but the exact reason is unknown. Researchers suggest it might be secondary to hormonal changes, decreased immune function, hypertension or diabetes in obese patients.
"Although we still need to find out more about the pathology of clear-cell RCC, this study is useful as it provides individual predictors of the chance of developing this form of cancer. Of these, obesity provides the strongest association."
(Source: www.sciencedaily.com)
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