Scientists from Monash University in Melbourne, Australia, have identified a protein released by fat cells that desensitizes the liver and muscles to insulin. In large amounts, the protein, called PEDF (pigment epithelium-derived factor), forces the pancreas to produce insulin to help neutralize the desensitization. Eventually, the overworked pancreas begins to slow down significantly or even stop producing insulin altogether. When this happens, the individual develops type 2 diabetes.
People who are obese have significantly more fat cells than people of average weight and so produce a much larger amount of PEDF. This increased PEDF production is what eventually leads to type 2 diabetes. Researchers hope that the discovery of a chemical link between obesity and type 2 diabetes will aid experts in developing treatments for type 2 diabetes.
(Source: diabeteshealth.com)
Labels: obesity, type 2 diabetes, diabetes
Posted By: Aspen Education Group